Tamoxifen disrupts the reproductive process in gilthead seabream males and modulates the effects promoted by 17alpha-ethynylestradiol
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AuthorsGarcía-Hernández, M.P. (María del Pilar); Rodenas, M.C. (María del Carmen); Cabas, I. (Isabel); García-Alcázar, A. (Alicia); Chaves-Pozo, E. (Elena); García-Ayala, A. (Alfonsa)
KeywordsTamoxifen, 17alpha-ethynylestradiol, endocrine disruption reversibility, spermatogenesis, steroidogenesis, gilthead seabream
17α-ethynylestradiol (EE2), which is used in oral contraceptives and hormone replacement therapy, is a well documented estrogenic endocrine disruptor and an aquatic contaminant. In the present study, adult male specimens of the marine hermaphrodite teleost gilthead (Sparus aurata L.) were fed a diet containing tamoxifen (Tmx), an estrogen receptor ligand used in cancer therapy, alone or combined with EE2, for 25 days and then fed a commercial diet for a further 25 days (recovery period). The effects of short (5 days) and long (25 days) treatments on several reproductive and gonad immune parameters and the reversibility of the disruptive effects after the recovery period were examined. Our data showed that Tmx acted as an estrogenic endocrine disruptor as revealed by the increase in the hepatic transcription of the vitellogenin gene in males, the serum levels of 17β-estradiol and the gonad expression levels of the estrogen receptor α and G protein-coupled estrogen receptor genes, and the ...
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