Energy metabolism of hyperthyroid-induced gilthead sea bream Sparus aurata L.
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Autor/esVargas-Chacoff, L.; Ruiz-Jarabo, I.; Arjona, F.J. (Francisco J.); Laiz-Carrión, R. (Raúl); Flik, G.; Klaren, P.H.; Mancera, J.M.
Palabras clave3,5,3′-Triiodo-l-thyronine (T3); Energy metabolism; Protein catabolism; Lipid catabolism; Osmoregulation; Sparus aurata
Thyroid hormones, in particular 3,5,3′-triiodothyronine or T3, are involved in multiple physiological processes in mammals such as protein, fat and carbohydrate metabolism. However, the metabolic actions of T3 in fish are still not fully elucidated. We therefore tested the effects of T3 on Sparus aurata energy metabolism and osmoregulatory system, a hyperthyroid-induced model that was chosen. Fish were implanted with coconut oil depots (containing 0, 2.5, 5.0 and 10.0 μg T3/g body weight) and sampled at day 3 and 6 post-implantation. Plasma levels of free T3 as well as glucose, lactate and triglyceride values increased with increasing doses of T3 at days 3 and 6 post-implantation. Changes in plasma and organ metabolite levels (glucose, glycogen, triglycerides, lactate and total α amino acid) and enzyme activities related to carbohydrate, lactate, amino acid and lipid pathways were detected in organs involved in metabolism (liver) and osmoregulation (gills and kidney). Our data implicate ...
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