Antimicrobial response is increased in the testis of European sea bass but not in gilthead seabream upon nodavirus infection
MetadataShow full item record
AuthorsValero-Cuesta, Y. (Yulema); García-Alcázar, A. (Alicia); Esteban, M.A. (María de los Ángeles); Cuesta, A. (Alberto); Chaves-Pozo, E. (Elena)
Antimicrobial peptides (AMPs) have a crucial role in the fish innate immune response, being considered a fundamental component of the first line of defence against pathogens. Moreover, AMPs have not been studied in the fish gonad since this is used by some pathogens as a vehicle or a reservoir to be transmitted to the progeny, as occurs with nodavirus (VNNV), which shows vertical transmission through the gonad, and/or gonadal fluids but no study has looked into the gonad of infected fish. In this framework, we have characterized the antimicrobial response triggered by VNNV in the testis of European sea bass, a very susceptible species of the virus, and in the gilthead seabream, which acts as a reservoir, both in vivo and in vitro, and compared with that present in the serum and brain (target tissue of VNNV). First, our data show a great antiviral response in the brain of gilthead seabream and in the gonad of European sea bass. In addition, for the first time, our results demonstrate that ...
The following license files are associated with this item: