Evidence for lipid alterations in lipid rafts from alzheimer´s disease human brain.
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Díaz, M.; Martín, M.V. (María Virginia); Fabelo, N.; Santpere, G. (Gabriel); Puig, B.; Marín, R.; Alonso, R.; Gómez, T.; Pérez, J.A.; Ferrer, I.Date
2010Type
book partAbstract
Lipid rafts are membrane microdomains involved in cell signalling and characterized by their high contents of sphingolipids, cholesterol and saturated fatty acids.
In this study, we have purified lipid rafts of human frontal brain cortex from normal
and Alzheimer’s disease (AD) cell membranes and analyzed their lipid composition.
Compared to non-AD brains, lipid rafts from AD brains displayed low levels of n-3
long chain highly unsaturated fatty acids (HUFA) specially 22:6n-3 (docosahexaenoic
acid) and n-9 monoenes (specially 18:1n-9, oleic acid). Changes in lipid structure of
AD lipid rafts also involved significant reductions in the unsaturation and peroxidability indexes as well as increased unsaturated/cholesterol unsaturated/sphingomyelin
and saturates/n-3 HUFA ratios. These results indicate that the mechanisms preserving
lipid raft order and viscosity in normal frontal cortex are disrupted in AD brains,
which partially might ...