Effect of 17alpha-ethynylestradiol on steroidogenesis and gonadogenesis in wean gilthead seabream larvae
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AuthorsCabas, I. (Isabel); Rodenas, M.C. (María del Carmen); García-Hernández, M.P. (María del Pilar); García-Alcázar, A. (Alicia); Meseguer, J. (José); Mulero, V. (Victoriano); Chaves-Pozo, E. (Elena); García-Ayala, A. (Alfonsa)
Keywordsendocrine disrupter, steroidogenesis, larvae, gilthead seabream
A wide variety of chemicals discharged from industrial and municipal sources have been reported to disrupt the endocrine system of animals, which may be exposed via the food chain and contaminated water. 17α-ethinylestradiol (EE2), a drug used in oral contraceptives and hormone replacement therapy, has a widespread presence in the aquatic environment. Current knowledge on the sensitivity of marine fish reproductive system to estrogenic environmental chemicals is limited. Interestingly, the resistance of EE2 to degradation should not be underestimated and for instance, determining the impact of the intake of low levels of EE2 with the food on fish reproduction is mandatory. We report here the effects of dietary intake of EE2 on gilthead seabream recently weaned larvae (50 days post-hatching, dph) during 100 days of exposure (150 dph) on the gene expression profile of several steroidogenic-relevant genes and T, E2 and 11KT larvae levels in order to asses the degree of endocrine disruption ...
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