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dc.contributor.authorAyala, M.D. (María Dolores)
dc.contributor.authorGómez, V. (Victoria)
dc.contributor.authorCabas, I. (Isabel)
dc.contributor.authorGarcía Hernández, M.P. (María Pilar)
dc.contributor.authorChaves-Pozo, E. (Elena) 
dc.contributor.authorArizcun-Arizcun, M. (Marta) 
dc.contributor.authorGarcía de la Serrana, D. (Daniel)
dc.contributor.authorGil, F. (Francisco)
dc.contributor.authorGarcía-Ayala, A. (Alfonsa)
dc.date.accessioned2021-12-22T13:41:38Z
dc.date.available2021-12-22T13:41:38Z
dc.date.issued2021-12-07
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10508/15650
dc.description.abstractEndocrine-disrupting chemicals include natural and synthetic estrogens, such as 17α- ethynilestradiol (EE2 ), which can affect reproduction, growth and immunity. Estrogen signalling is mediated by nuclear or membrane estrogen receptors, such as the new G-protein-coupled estrogen receptor 1 (GPER1). The present work studies the effect of EE2 and G1 (an agonist of GPER1) on body and muscle parameters and growth-related genes of 54 two-year-old seabreams. The fish were fed a diet containing EE2 (EE2 group) and G1 (G1 group) for 45 days and then a diet without EE2 or G1 for 122 days. An untreated control group was also studied. At 45 days, the shortest body length was observed in the G1 group, while 79 and 122 days after the cessation of treatments, the shortest body growth was observed in the EE2 group. Hypertrophy of white fibers was higher in the EE2 and G1 groups than it was in the control group, whereas the opposite was the case with respect to hy- perplasia. Textural hardness showed a negative correlation with the size of white fibers. At the end of the experiment, all fish analyzed in the EE2 group showed a predominance of the gonadal ovarian area. In addition, the highest expression of the mafbx gene (upregulated in catabolic signals) and mstn2 (myogenesis negative regulator) was found in EE2 -exposed fish.es_ES
dc.language.isoenges_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectEE2 ; GPER1; body growth; muscle cellularity; muscle growth regulator geneses_ES
dc.titleThe Effect of 17α-Ethynilestradiol and GPER1 Activation on Body and Muscle Growth, Muscle Composition and Growth-Related Gene Expression of Gilthead Seabream, Sparus aurata Les_ES
dc.typearticlees_ES
dc.identifier.bibliographicCitationInternational Journal of Molecular Sciences, 23. 2021: 13118-13145*
dc.description.versionVersión del editores_ES
dc.relation.publisherversionwww.mdpi.com/1422-0067/22/23/13118/htmes_ES
dc.publisher.centreCentro Oceanográfico de Murciaes_ES
dc.relation.projectIDAGL2017-85978-C2-1-Res_ES
dc.rights.accessRightsopenAccesses_ES
dc.description.impact2,464*
dc.identifier.essn1422-0067*
dc.identifier.doi10.3390/IJMS222313118
dc.subject.asfafish es_ES
dc.subject.asfahistology es_ES
dc.subject.asfaAnimal growth es_ES
dc.subject.asfaMuscle fibers es_ES
dc.subject.asfaEndocrine disruptors es_ES


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    Atribución-NoComercial-SinDerivadas 3.0 España
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