The Effect of 17α-Ethynilestradiol and GPER1 Activation on Body and Muscle Growth, Muscle Composition and Growth-Related Gene Expression of Gilthead Seabream, Sparus aurata L
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Autor/esAyala, M.D. (María Dolores); Gómez, V. (Victoria); Cabas, I. (Isabel); García Hernández, M.P. (María Pilar); Chaves-Pozo, E. (Elena); Arizcun-Arizcun, M. (Marta); García de la Serrana, D. (Daniel); Gil, F. (Francisco); García-Ayala, A. (Alfonsa)
Versión del editorwww.mdpi.com/1422-0067/22/23/13118/htm
Palabras claveEE2 ; GPER1; body growth; muscle cellularity; muscle growth regulator genes
Endocrine-disrupting chemicals include natural and synthetic estrogens, such as 17α- ethynilestradiol (EE2 ), which can affect reproduction, growth and immunity. Estrogen signalling is mediated by nuclear or membrane estrogen receptors, such as the new G-protein-coupled estrogen receptor 1 (GPER1). The present work studies the effect of EE2 and G1 (an agonist of GPER1) on body and muscle parameters and growth-related genes of 54 two-year-old seabreams. The fish were fed a diet containing EE2 (EE2 group) and G1 (G1 group) for 45 days and then a diet without EE2 or G1 for 122 days. An untreated control group was also studied. At 45 days, the shortest body length was observed in the G1 group, while 79 and 122 days after the cessation of treatments, the shortest body growth was observed in the EE2 group. Hypertrophy of white fibers was higher in the EE2 and G1 groups than it was in the control group, whereas the opposite was the case with respect to hy- perplasia. Textural hardness ...
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