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dc.contributor.authorValero, Y. (Yulema) 
dc.contributor.authorLópez-Cánovas, A.E. (Amanda Esperanza)
dc.contributor.authorRódenas, M.C. (María del Carmen)
dc.contributor.authorCabas, I. (Isabel)
dc.contributor.authorGarcía-Hernández, M.P. (María del Pilar)
dc.contributor.authorArizcun-Arizcun, M. (Marta) 
dc.contributor.authorGarcía-Ayala, A. (Alfonsa)
dc.contributor.authorChaves-Pozo, E. (Elena) 
dc.date.accessioned2021-04-26T08:38:20Z
dc.date.available2021-04-26T08:38:20Z
dc.date.issued2020-05-14
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10508/11514
dc.description.abstract17α-ethynilestradiol (EE2) and tamoxifen (Tmx) are pollutants world-wide distributed in aquatic environments. Gilthead seabream, Sparus aurata L., is highlighted as a species model of intensively culture in anthropogenic disturbed environments. The effects of these pollutants on gilthead seabream reproduction and some immune responses have been described but, the humoral innate antimicrobial activities have never received attention. In this work we analysed the latest in the plasma of gilthead seabream males of different ages and reproductive stages treated with 0, 2.5, 5 or 50 μg EE2 or 100 μg Tmx g−1 food during different times of exposure and of reverting to commercial diet (recovery). The peroxidase and protease activities decreased as the spermatogenesis of the first reproductive cycle (RC) proceeded in control fish. However, only protease and antiprotease activities showed different level at different stages of the second RC in control fish, but showed scarce disruption in fish treated with EE2 or Tmx. Peroxidase and bactericide activities are more sensitive to EE2, than to Tmx. The effects induced by EE2 varied depending on the activity analyzed, the dose and the time of exposure and the reproductive stage and the age of the specimens.es_ES
dc.language.isoenges_ES
dc.relation.isversionofEditores_ES
dc.relation.isreferencedbyhttp://www.nature.com/articles/s41598-020-64522-2es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectdisrupter chemicalses_ES
dc.subjecthumoral innate activitieses_ES
dc.subjectsparus aurataes_ES
dc.subjectendocrine disruptiones_ES
dc.titleEndocrine disrupter chemicals affect the humoral antimicrobial activities of gilthead seabream males even upon the cease of the exposurees_ES
dc.typeresearch articlees_ES
dc.identifier.bibliographicCitationScientific Reports, 10. 2020: 7966-7977*
dc.type.hasVersionVoRes_ES
dc.relation.publisherversionw.nature.com/articles/s41598-020-64522-2es_ES
dc.publisher.centreCentro Oceanográfico de Murciaes_ES
dc.relation.projectIDMinisterio de Ciencia e Innovación and FEDER (AGL2013-43588-P, AGL2014- 53167-C3-2-R, AGL2017-85978-C2-1-R)es_ES
dc.rights.accessRightsopen accesses_ES
dc.description.impact2,927*
dc.identifier.doi10.1038/s41598-020-64522-2
dc.subject.asfafishes_ES
dc.subject.asfapollutantses_ES
dc.subject.asfamaleses_ES
dc.subject.asfaworldes_ES
dc.subject.asfareport literaturees_ES


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    Atribución-NoComercial-SinDerivadas 3.0 España
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