Genes related to cell-mediated cytotoxicity and interferon response are induced in the retina of European sea bass upon intravitreal infection with nodavirus
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AuthorsValero, Y. (Yulema); Boughlala, B. (Bassima); Arizcun-Arizcun, M. (Marta); Patel, S. (Sonal); Fiksdal, I.U. (Ingrid U.); Esteban, M.A. (María Ángeles); De Juan, J. (Joaquín); Meseguer, J. (José); Chaves-Pozo, E. (Elena); Cuesta, A. (Alberto)
European sea bass
innate immune response
adaptative immune response
Viral diseases are responsible for high rates of mortality and subsequent economic losses in modern aquaculture. The nervous necrosis virus (NNV) produces viral encephalopathy and retinopathy (VER), which affects the central nervous system, is considered one of the most serious viral diseases in marine aquaculture. Although some studies have localized NNV in the retina cells, none has dealt with immunity in the retina. Thus, for the first time, we intravitreally infected healthy specimens of European sea bass (Dicentrarchus labrax) with NNV with the aim of characterizing the immune response in the retina. Ultrastructural analysis detected important retinal injuries and structure degradation, including pycnosis, hydropic degeneration and vacuolization in some cell layers as well as myelin sheaths in the optic nerve fibres. Immunohistochemistry demonstrated that NNV re- plicated in the eyes. Regarding retinal immunity, NNV infection elicited the transcription of genes encoding proteins ...
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