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dc.contributor.authorGarcía-García, M. (María)
dc.contributor.authorLiarte, S. (Sergio)
dc.contributor.authorGómez-González, N.E. (Nuria Esther)
dc.contributor.authorGarcía-Alcázar, A. (Alicia) 
dc.contributor.authorPérez-Sánchez, J. (Jaume)
dc.contributor.authorMeseguer, J. (José)
dc.contributor.authorMulero, V. (Victoriano)
dc.contributor.authorGarcía-Ayala, A. (Alfonsa)
dc.contributor.authorChaves-Pozo, E. (Elena) 
dc.date.accessioned2016-08-16T11:13:12Z
dc.date.available2017-08-16T02:45:10Z
dc.date.issued2016-07-27
dc.identifier.issn1532-0456*
dc.identifier.urihttp://hdl.handle.net/10508/10222
dc.description.abstractThe importance of histamine in the physiology of the testis in mammals and reptiles has been recently shown. Histamine receptors (Hrs) are well conserved in fish and are functional in several fish species. We report here for the first time that histamine and the mRNA of Hrh1, Hrh2 and Hrh3 are all present in the gonad of the hermaphrodite teleost fish gilthead seabream. Moreover, cimetidine, which acts in vitro as an agonist of Hrh1 and Hrh2 on this species, was intraperitoneally injected in one and two years old gilthead seabream males. After three and five days of cimetidine injection, we found that this compound differently modified the gonadal hrs transcript levels and affects the testicular cell renewal and the gene expression of steroidogenesis-related molecules as well as the serum steroid levels. Our data point to cimetidine as a reproductive disruptor and elucidate a role for histamine in the gonad of this hermaphrodite fish species through Hr signalling.es_ES
dc.language.isoenges_ES
dc.relation.isversionofhttp://www.ncbi.nlm.nih.gov/pubmed/27475025es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectCimetidinees_ES
dc.subjectHistamine receptorses_ES
dc.subjecthermaphrodite fishes_ES
dc.subjecttestises_ES
dc.titleCimetidine disrupts the renewal of testicular cells and the steroidogenesis in a hermaphrodite fishes_ES
dc.typearticlees_ES
dc.identifier.bibliographicCitationComparative Biochemistry and Physiology C-Toxicology & Pharmacology, 189. 2016: 44-53*
dc.description.versionPostprintes_ES
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S153204561630076Xes_ES
dc.date.embargoEndDate2017-08-16es_ES
dc.publisher.centreCentro Oceanográfico de Murciaes_ES
dc.relation.projectIDAGL2014-53167-C3-1-R, AGL2014-53167-C3-2-R AGL2010- 20801-C02-20-01, RYC-2009-05451es_ES
dc.rights.accessRightsembargoedAccesses_ES
dc.description.impact2,6160*
dc.identifier.doi10.1016/j.cbpc.2016.07.004es_ES


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